The major findings of this report are as follows: (1) acute inflammation in the colonic mucosa is associated with increased SIRT7 and decreased SIRT1 levels; (2) inhibition of SIRT7 reduces the expression of inflammatory cytokines; and (3) measurements of the length, weight, and stool characteristics of the mice confirms that treatment with SIRT7 inhibitors effectively improves colitis. Here, SIRT7 is linked to colitis.