In contrast, the phospho-AMPK and Akt/mTOR signaling pathways were activated in OR CRC cells, reducing tumor-suppressive autophagy, which protects these cells by increasing the levels of enzymes involved in glycolysis, especially GLUT1, PFKFB3 and PFK1, thereby maintaining resistance to oxaliplatin. This evidence concerns the gene PFKM and colorectal carcinoma.