Oxaliplatin treatment in PT CRC cells inhibited their proliferation by decreasing phospho-Akt, followed by decreasing phospho-mTOR and other downstream molecules, such as phospho-p70S6K and phospho-S6RP, resulting in the induction of tumor-suppressive autophagy in ST CRC cells. The gene discussed is RPS6KB1; the disease is colorectal carcinoma.