It is possible that the progression of cardiovascular diseases may be due to the inactivating effect of CYP3A4 on the active form of vitamin D because a low concentration of 1,25(OH)2D3 in blood serum is strongly associated with the initiation of cardiovascular diseases [372] and with the incidence of arterial hypertension [373]. Here, CYP3A4 is linked to Hypertension.