CYP3A4 and COVID-19: It has also been reported that CYP3A enzymes can have an effect on COVID-19 pathophysiology through arachidonic acid metabolites and vitamin D. For example, arachidonic acid metabolism is one of the most affected metabolic pathways during SARS-CoV-2 infection [331], and EETs (whose production is catalyzed by CYP3A enzymes) play a role in kidney damage in this context [332].