CYP3A4 and hepatocellular carcinoma: In contrast to CYP3A4, aberrantly low CYP3A5 expression in HCC and a negative association between CYP3A5 expression and HCC malignant characteristics have been detected in a large HCC cohort; several reports show that CYP3A5 can act as an HCC suppressor and can counteract the malignant tumor phenotype [438,439].