We already mentioned that CYP3A4 participates in breast cancer progression by stimulating angiogenesis through VEGF activation [309,310,320] and by promoting cancer cell proliferation through the activation of PI3 kinase–AKT and STAT3 pathways, in part via the synthesis of (+/−)-14,15-EET [313]. The gene discussed is CYP3A4; the disease is breast cancer.