CYP3A4 and neoplasm: In another research article, analysis of CYP3A4 and CYP3A5 expression in tumor tissue of children with nonrhabdomyosarcoma soft tissue sarcomas also showed that in such patients, mRNA and protein expression levels of these genes are significantly higher in the tumor tissue than in nonmalignant neighboring tissue; estimated 5-year relative survival of the treated patients is ~50% because they typically present with tumor progression, recurrence, metastasis, and/or resistance to chemotherapy [435].