For instance, after an assay of the activity of seven major CYP enzymes in 38 patients with type 2 diabetes mellitus and 35 patients without diabetes (oral administration of the midazolam as a probe drug), it turned out that the activity of CYP3A enzymes in patients with diabetes mellitus is lower by approximately 38% [382]. The gene discussed is PPIG; the disease is type 2 diabetes mellitus.