CYP3A4 takes part in breast cancer progression by stimulating angiogenesis through the activation of vascular endothelial growth factor (VEGF) [309,310,320] and in cancer cell proliferation through the activation of phosphatidylinositol 3-kinase (PI3K)–protein kinase B (AKT) and STAT3 pathways partially because of the synthesis of (+/−)-14,15-EET [313]. Here, AKT1 is linked to breast cancer.