CYP3A5 and hepatocellular carcinoma: There is evidence that forced expression of CYP3A5 dramatically suppresses migration and invasion of HCC cells in vitro via inhibition of ROS–mTORC2–p-AKT signaling, and consequently CYP3A5-induced ROS accumulation is a key regulator of the activity of mTORC2: a serine/threonine kinase that translates external stimuli into processes related to cell growth.