Although the number of animals was low (n = 16), we demonstrated that the heterozygous genotype for the rs41976219 (AC) resulted in higher CTSG protein levels in the supernatants of infected CD14+-MDMs following 2 h of infection and significantly lower intracellular MAP load at 7 d p.i. than in MDMs from cattle with the AA genotype. Here, CTSG is linked to infection.