In addition, the DEGs were enriched in 19 KEGG pathways (p < 0.05, Figure 3B) and the 19 pathways were related with hormone (e.g., Cushing syndrome, insulin secretion, and renin-angiotensin system) and neurotransmitter transmission (e.g., neuroactive ligand-receptor interaction, dopaminergic synapse, synaptic vesicle cycle, and cholinergic synapse). The gene discussed is INS; the disease is Cushing syndrome due to macronodular adrenal hyperplasia.