HLA-DRB1 and idiopathic interstitial pneumonia: Moreover, via genome-wide genotype imputation association analyses, two strongly linked HLA alleles were found to be associated with fibrotic idiopathic interstitial pneumonia HLA-DRB1*15:01 and -DQB1*06:02, affecting the expression of HLA genes in lung tissue and indicating that the potential genetic risk due to HLA alleles may involve gene regulation in addition to an altered protein structure [16].