NFE2L2 and cancer: Figure 3B shows the tissue region displaying high NQO1 expression in pan-cytokeratin-positive cancer cells, with negative NQO1 expression observed in stromal cells and immune cells. Conversely, NRF1 and NRF2 expression in these same cancer cells were lower than the expression of NRF1 and NRF2 in lymphoid cells, which are high, as seen in Figure 3B).