We found that PsychiPPI identified DD candidate genes were significantly enriched in DD-related curated pathogenic gene sets, such as developmental delay gene set (Count: 19, p-Value < 0.001), Constraint gene set (Count: 17, p-Value < 0.001), FMRP target gene set (Count: 7, p-Value = 1.58 × 10−3) (Figure 3b), we also observed SMAD3, a candidate gene with limited literature studies, is also included in the Developmental delay gene set (Figure 3a). Here, SMAD3 is linked to Global developmental delay.