Additionally, DMC increases ROS and Ca2+ production and elevates the production of ER stress-related proteins, such as GRP78, GADD153, IRE1α, IRE1β, ATF-6α, ATF-6β, and caspase-4, demonstrating the beneficial effects of promoting NSCLC apoptosis [127]. The gene discussed is HSPA5; the disease is non-small cell lung carcinoma.