Moreover, studies on MDSCs in Tnfr1–/– and Tnfr2–/– tumor-bearing mice have shown that tmTNF requires TNFR2 to mediate the activation of NF-κB and p38 signaling pathways, which activate the immunosuppressive function of MDSCs [30]. The gene discussed is TNFRSF1A; the disease is neoplasm.