Because there are two types of TNFR, signals mediated by TNFR2 are necessary and sufficient to protect MDSCs from apoptosis, while TNFR1 deletion has no significant effect on tumor growth, MDSC recruitment, the NF-κB signaling pathway, or induction of apoptosis [40]. The gene discussed is TNFRSF1A; the disease is neoplasm.