IL10 and neoplasm: They incubated MDSCs from tumor-bearing mice with sTNF, tmTNF, or their neutralizing antibodies, and found that tmTNF-α activated MDSCs with enhanced suppressive activities, including upregulating arginase-1 and inducible NO synthase transcription, promoting secretion of NO, ROS, IL-10, and TGF-β, and enhancing the inhibition of lymphocyte proliferation.