While all of the aforementioned studies indicated that GSDMD acted as an executor and contributor to renal I/R injury, a recent study by Tonnus et al. found that GSDMD-deficient mice are hypersensitive to I/R-induced acute kidney injury (AKI) and demonstrated that GSDMD functioned as a suppressor of I/R-induced AKI through a previously unknown non-cell autonomous crosstalk to necroptosis [103]. Here, GSDMD is linked to acute kidney injury.