OXT and obesity due to melanocortin 4 receptor deficiency: Lastly, Wu et al. [145] examined the effect of caffeine on PVN oxytocin neurons and regulation of energy balance in DIO mice, while Yuan J. et al. showed that C57BL6/J mice fed with high fat diet are in accordance with others, suggesting that chronic administration of oxytocin ameliorates obesity and metabolic dysfunctions [146].