High fat diet-fed rats, on the other hand, have been used to study the fat loss following chronic CNS oxytocin signaling [151] or chronic hindbrain administration [152], the mechanisms for the anti-obesity effects of oxytocin [153,154] and the combined effect of oxytocin with beta-3 receptor agonist to body weight and adiposity [155]. Here, OXT is linked to obesity due to melanocortin 4 receptor deficiency.