We used AD1 and AD2 datasets for training and test sets in both directions and found six transcripts (MRPL51, NDUFA1, NDUFS5, two Illumina probes for RPL36AL, and LOC646200 (similar to 60S ribosomal protein L22, Heparin binding protein HBp15)) were selected in both sessions, highlighting the importance of mitochondrial and ribosome malfunction in Alzheimer’s disease. The gene discussed is RPL22; the disease is early-onset autosomal dominant Alzheimer disease.