However, so far, only one FASN inhibitor has entered clinical trials (TVB-2640 from Sagimet Biosciences) as shown in Table 1B. This compound has demonstrated potent FASN inhibition as well as a favorable and manageable safety profile, characterized by very limited, non-serious, reversable adverse events when tested in patients with previously treated advanced metastatic solid tumors, including 4 PCa patients [435]. This evidence concerns the gene FASN and posterior cortical atrophy.