AR signaling governs PCa metabolism by regulating components in the glycolytic pathway (glucose transporter GLUT1, hexokinase HK1, HK2, and 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase PFK2/PFKFB) and in pyruvate flux into mitochondria (PDH and mitochondrial pyruvate carrier MPC2). The gene discussed is PFKFB3; the disease is posterior cortical atrophy.