Aberrantly expressed, circRNAs play an important role in glioma proliferation, cell cycle, invasion, and metastasis via regulating complementary miRNAs or targeting mRNA that are related to tumor-associated signaling pathways, such as PI3K/AKT/mTOR and the Wnt/β-catenin pathway [100]. The gene discussed is AKT1; the disease is glioma.