Previous studies have revealed that TCRP1 is a target gene for c-Myc [148], a protein that regulates the phosphoinositide-dependent kinase 1 (PDK1)/serum- and glucocorticoid-inducible kinase 1 (SGK1) [149] and PI3K/AKT/NF-κB [150] signaling pathways, promoting TCRP1 transcription to render tumor cells resistant to chemotherapeutic agents. This evidence concerns the gene AKT1 and neoplasm.