All pathways were closely connected with each other and enriched in adaptive immune system, cysteine and methionine metabolism, TP53 regulates metabolic genes, positive regulation of mRNA process, etc. The physiological interactions between these activities may contribute to metabolic disorders and apoptosis of optic nerve cells in LHON patients (m.G11778A). This evidence concerns the gene TP53 and Leber hereditary optic neuropathy.