It was shown that reduced expression of cannabinoid receptor-interacting protein 1 (CNRIP1) was associated with enhanced DNA methylation of a CpG island site named CNRIP1 MS-2 (CNRIP1 methylation site-2) in intrahepatic cholangiocarcinoma (ICC) cells [102]. Here, CNRIP1 is linked to intrahepatic cholangiocarcinoma.