IGF-2 analog [Leu27]IGF-2 can specifically activate IGF-2R, and the transfection of [Leu27]IGF-2 into rat cardiomyocytes by adenovirus can induce reconstruction characterized by pathological hypertrophy, myocardial fibrosis, and cardiomyocytes’ apoptosis accompanied by massive collagen deposition [89]. Here, IGF2R is linked to Myocardial fibrosis.