In recent days, there has been an attempt to use Alda-1, a molecular-weight activator of ALDH2, which has been shown to attenuate 4-HNE adduction in various pathological conditions such as stroke, hyperoxia-induced lung injury, hypoxia-induced pulmonary hypertension, hepatic ischemia-reperfusion injury, and atherosclerosis [42,43,44,45,46]. This evidence concerns the gene ALDH2 and Stroke.