AGT and acute kidney injury: For example, therapeutic drugs of different pharmacological classes (e.g., anti-cancer and antibiotics agents), heavy metals (e.g., Pb and Hg2+), exogenous toxins (e.g., insecticides, snake and spider poisons and industrial chemicals) and endogenous vasoactive peptides (e.g., angiotensin II) might cause renal damage with varying severity, which might range from tubular dysfunctions to severe renal failure, occasionally leading to death [111,112,113,114,115,116].