SIRT3 and neoplasm: However, and adding to the discrepancy, Wang et al. and Ma et al. found that overexpression of SIRT3 in the GC AGS cell line reduces cell proliferation, colony formation capacity, and invasion, and decreases tumor growth in nude mice [97,98,101], whereas Cui and co-workers reported the opposite effect showing that overexpression of SIRT3 in the same GC cell line stimulates proliferation [100].