For instance, higher glucose uptake via glucose transporter 1 (GLUT1) and sodium-glucose cotransporter 2 (SGLT2) is required for cancer cells to accomplish conversion to pyruvate and then metabolize pyruvate to lactate, which acidifies the microenvironment and further favors the polarization of tumor-associated macrophages (TAMs), enhancing the migration and invasive abilities of tumor cells [88,89]. The gene discussed is SLC5A2; the disease is cancer.