Adeola et al. revealed that mTORC1 activation is caused by GS-mediated glutamine synthesis, correlated with upregulated β-catenin signaling and phosphorylation of mTOR-S2448 in human HCC, thus revealing the relationship in the GS/glutamine/p-mTOR-S2448 axis [109]. This evidence concerns the gene MTOR and hepatocellular carcinoma.