AKT1 and pachyonychia congenita: Interestingly, a pan-AKT inhibitor MK-2006 diminished overexpression of CD133 induced Wnt activation, indicating a CD133/AKT/Wnt signaling axis may play a role in regulating the stemness of glioblastoma [76].In PC, non-adherent prostaspheres cultures enriched stemness characteristics of prostate cell likes.