Following a B-cell receptor activation and triggering of the PI3K/AKT signaling pathway, MYC-mediated PRMT5 transcription induces cell cycle progression, increasing cell survival and proliferation in both activated B-cell (ABC) and germinal center (GC) diffuse large B-cell lymphoma (DLBCL). The gene discussed is PRMT5; the disease is diffuse large B-cell lymphoma.