The third phase is called escape, and it occurs due to the following reasons: the loss of tumor antigens and subsequent loss of immune recognition of tumor cells [37,38]; an increase in secretion of cytokines such as TGF-β [39,40,41], IL-10 [42,43,44], and VEGF [45,46,47]; an increase in transcription factors such as STAT3 [48,49] and BACH2 [50,51]; and overexpression of molecules such as PDL1 and CTLA4, which act as a bridge to inhibit recognition by immune cells. This evidence concerns the gene CTLA4 and neoplasm.