Interestingly, transgenic mouse models that expressed either human ATX, LPAR1, LPAR2 or LPAR3 displayed spontaneous development of breast tumors [9], while in human BC MDA-B0-2 cells, overexpression of ATX or LPAR1 resulted in invasion, bone metastasis and destruction [81,82]. The gene discussed is ENPP2; the disease is breast neoplasm.