Other major genes associated with higher BC incidence include phosphatase and tensin homolog (PTEN) [10], tumor-suppressor protein TP53 [11], CDH1 (which encodes epithelial cadherin or E-cadherin (E-cad) protein) [12], and serine/threonine kinase 11 (STK11) [13,14,15]. Here, PTEN is linked to breast cancer.