HSPA5 and glioblastoma: Another important protein of the Hsp70 family, GRP78/BiP protein, is significantly overexpressed in glioblastoma, as was confirmed by the immunohistochemistry [87], proteomics [88], western blot analysis of cell lines, and immunohistochemistry of in vivo grown tumors [89], and in vivo in xenografted mice models [90].