Despite the opposing findings on the effect of Hsp90 on the survival of patients, experimental studies show that inhibition of the Hsp90 ATPase domain with Shepherdin, a peptidomimetic antagonist of the complex between the chaperone and survivin, resulted in induction of autophagy in glioblastoma cells and suppression of tumor growth in mice model (immunocompromised CB17 SCID/beige female mice), as well as longer survival [99]. This evidence concerns the gene HSP90AA1 and glioblastoma.