The STK11 mutation-induced downregulation of immune checkpoint regulating proteins, like PD-L1 and T-cell chemokines, favored a ‘‘cold’’ immunosuppressive tumor microenvironment (TME) and contributed to the exclusion of inflamed immune cells, such as CD4+ T cells, CD8+ T cells, natural killer (NK) cells, and Macrophage type 1 (M1), from driving the tumor immune escape [18]. The gene discussed is CD274; the disease is neoplasm.