The main clinicopathological and molecular parameters that correlated with L1CAM positivity were non-endometrioid histological type (p < 0.001), advanced FIGO stage (p = 0.041), G3 tumor grade (p = 0.018), high and advanced risk group (p = 0.002), p53abn (p < 0.001), MMR proficiency (p < 0.001), lower expression of ER and PR (both p < 0.001), and presence of ARID1A expression (p = 0.035, Appendix A, Table A4). Here, L1CAM is linked to neoplasm.