Cervical cancer-secreted exosomal miR-1468-5p epigenetically activates the JAK2/STAT3 pathway in lymphatic endothelial cells by directly targeting homeobox containing 1 (HMBOX1) in the SOCS1 promoter, activating an immunosuppressive program that allows cancer cells to escape anti-cancer immunity [34]. The gene discussed is HMBOX1; the disease is cancer.