RBPJ and central nervous system cancer: Although Trp53-/-Rbpj-/- tumors are clearly separable from PDGF+Trp53-/-Rbpj-/- tumors at the transcriptional level [28], it is conceivable that tumor cells in both models acquire oligodendrocyte progenitor cell (OPC)-like features, a cellular state that is associated with a proneural glioma transcriptional subtype and a tumor suppressor role of Notch signaling [20].