M2 TAMs secrete pro-tumor factors (such as IL-4, IL-6, IL-10, IL-13, EGF, and VEGF), while the tumor suppressor M1 TAMs expresses anti-tumor factors (such as IL-12, the major histocompatibility complex (MHC) class II, and TNF-α) [53]. Here, IL6 is linked to neoplasm.