Increased infiltration of TILs (CD3+, CD4+, CD8+ and CD20+ B cells) and CD68+ macrophages in tumor microenvironment.Peritumoral accumulation of CD4+ T cells.Predominance of intratumor CD8+ over CD4+ T cells.Higher CD20+ cells were associated with decreased tumor size.Increased survival rates associated with intratumor CD3+ and CD20+ cells. The gene discussed is CD4; the disease is neoplasm.