Pembrolizumab, for example, binds to and impairs the lymphocyte PD-1 receptor’s ability to interact with PD-L1 on cancer cells and thus allows the enhancement of antitumor immune response via suppression of the co-inhibitory PD-1/PD-L1 pathway [6], which has resulted in a significantly better response and survival in certain patients with advanced/metastatic NSCLC [7,8,9]. The gene discussed is CD274; the disease is cancer.