Obesity signaling enhances E2 biosynthesis [10] and E2 function as a potent inducer of leukemia inhibitory factor (LIF) [11,12,13], which mediate its signaling using a receptor complex comprising LIFR and glycoprotein 130 (gp130) [14]. The gene discussed is LIFR; the disease is obesity due to melanocortin 4 receptor deficiency.