NTRK1 and cancer: Receptors such as retinoic acid receptor-related orphan receptors (RORs) have been implicated in the function of MDSC and may also be the target of some natural products [34], as well as the non-receptor tyrosine kinases (NRTK) expressed in hematopoietic cells, opening an interesting field in the search for natural modulators of suppression in cancer [35].