Likewise, the basal frequency and the response to therapy of CD4+ and CD8+ T cells was greater in 4T1 than in the B16-F10 murine model, suggesting that 4T1 is a hotter tumor than B16-F10, which may be conditioned by the intrinsic differences of each model and its relationship with the tumor microenvironment. This evidence concerns the gene CD8A and neoplasm.