MAPT and cancer: Regarding its functions, cumulative studies are suggesting that the role of Tau goes far beyond its microtubule-stabilizing function and that Tau is involved in many key signaling pathways, such as cell differentiation and proliferation, morphogenesis, motility, etc. At first sight, the microtubule-stabilizing function of Tau appears relevant to cancer because the microtubule dynamic ensures several critical functions such as cell motility, cytoplasmic transport, and cell division [69].