EGFR and glioblastoma: Alteration of these receptors is commonly observed and at least one RTK was found altered in 67.3% of GBM; the EGFR in 57.4% of GBM, PDGFR in 13.1% of GBM, HGFR/c-MET in 1.6% of GBM and FGFR in 3.2% of GBM [125].