Recently, Berman’s team examined 543 cases of GBM from the TCGA, and the authors were able to shed light on core pathway alterations responsible for the occurrence and the progression of gliomas: EGFR, IDH1, NF1, PDGFRA, PIK3R1, PIK3CA, PTEN, RB1, and p53 [125]. This evidence concerns the gene PIK3CA and central nervous system cancer.