In the univariate Cox proportional hazard model, HIV infection [OR: 3.2 (1.3–7.6), p = 0.010], CNS invasion [OR: 3.9 (2.1–13.2), p = 0.030], chemotherapy without rituximab [HR: 4.7 (1.9–11.5), p = 0.001], serum albumin < 35.0 g/L [OR: 4.7 (2.0–11.2), p < 0.001], hemoglobin < 110.0 g/L [OR: 2.0 (0.8–4.7), p = 0.120] and IPI > 2.0 [OR: 4.0 (1.0–5.7), p = 0.054] were closely associated with 1-year mortality. This evidence concerns the gene ALB and HIV infectious disease.