Interestingly, there was a larger amount of global (i.e., all analyzed methylation sites) and local (i.e., assigned to distinct genomic regions) hypomethylation in glioblastomas with PD-L1 high expression (methylation differences of ≥10% with p-values of <0.05): 68% (8593 of 12,597) of all significantly different methylation sites were hypomethylated in PD-L1 high glioblastomas, 83% of tiling region CpGs (2110 of 2546), 83% of all promoter-associated CpGs (116 of 139), 76% of CpGs associated with genes (81 of 107) and 60% of CpGs associated with CpG islands (64 of 107). Here, CD274 is linked to glioblastoma.