The structure differences in CD276 in OSCC may induce the proliferation regulation in OSCC [69]; in Cal27 and SCC25 OSCC cell lines, CD276 upregulates the expression of HIF-1α via the PI3K/Akt/mTOR pathway, increases the uptake of glucose, and then enhances the Warburg effect, further promoting tumor growth [70]. This evidence concerns the gene AKT1 and neoplasm.