IDO1 also induces the activation of the Aryl hydrocarbon receptor (AhR), which further activates the Src-PTEN-PI3K/Akt-GSK-3β signal, which is associated with the activity of nuclear translocation of β-catenin, which is finally involved in the proliferation of HCC cells [83]. Here, AKT1 is linked to hepatocellular carcinoma.