In ovarian cancer, the overexpression of HVEM (TNFRSF14), a member of the TNF receptor superfamily, is associated with the activation of AKT/mTOR signaling, promoting the expression of Bcl-2 and HIF-1α, which is positively associated with tumor proliferation and negatively related to cell apoptosis [110]. This evidence concerns the gene BCL2 and ovarian cancer.