More robust evidence was provided by the mentioned dPCR Jensen study [49], which reported a significant relationship between circulating BRAFV600E and many features of disease aggressiveness in a cohort of BRAF-mutated PTC: high tumor size, gross extra-thyroidal extension, pulmonary micro-metastases, and high-risk American Thyroid Association (ATA) category [78]. Here, BRAF is linked to neoplasm.