Currently, the most common EC histotypes are divided into the following four types: (1) ultra-mutated DNA polymerase εexonuclease tumors (POLE) with a favorable prognosis; (2) microsatellite-unstable tumors or mismatch repair-deficient (MMR) tumor with an intermediate prognosis; (3) microsatellite stability (MSS)or non-specific molecular profile (NSMP) tumor with a moderate prognosis; (4) p53 mutant or high copy-number tumors (serous-like) with poor prognosis [9]. This evidence concerns the gene TP53 and neoplasm.