In our review, the disassembly of the E-cadherin/β-catenin complex is the main EMT mechanism by which Fn promotes CRC metastasis, E-cadherin mediates Fn adhesion to epithelial cells, and β-catenin regulates cell growth and cell–cell adhesion in the maintenance of epithelial cell layers (Figure 3). The gene discussed is FN1; the disease is colorectal carcinoma.