Zhang et al. [51] discovered that Fn could promote CRC cell adherence to endothelial cells, extravasation, and migration by activating NF-κB signaling, and the cell surface adhesion molecule ICAM1 was also shown to be upregulated due to the phosphorylation of p65 subunit of NF-κB. Here, NFKB1 is linked to colorectal carcinoma.