Guo P et al. [26] established a cell-derived xenograft (CDX) mouse model exposed to Fn or FadA knockout (FadA−/− Fn) and found that Fn treatment increased the expression of the cell proliferation markers Ki-67 and PCNA, while FadA−/− Fn decreased the levels of E-cadherin/β-catenin and chk2 in CRC cells. This evidence concerns the gene CHEK2 and colorectal carcinoma.