FN1 and colorectal carcinoma: Guo P et al. [26] established a cell-derived xenograft (CDX) mouse model exposed to Fn or FadA knockout (FadA−/− Fn) and found that Fn treatment increased the expression of the cell proliferation markers Ki-67 and PCNA, while FadA−/− Fn decreased the levels of E-cadherin/β-catenin and chk2 in CRC cells.