Using Fn in a co-culture with EDMs, Sayed et al. [64] found that the expression of NEIL2 (a DNA glycosylase) was significantly suppressed among the key DNA repair proteins, while the levels of inflammatory cytokines and double-strand breaks in EDM cells were higher with NEIL2-null, which might favor the development of CRC. Here, NEIL2 is linked to colorectal carcinoma.