A hierarchical study evaluated the sensitivity of MM cells to inhibitors of anti-apoptotic proteins in the BCL-2 family (BCL-2, BCL-XL, BCL-W, A1, and MCL-1), and showed that the MCL-1 inhibitor is the most efficient among them [85], encouraging further study into inhibiting pro-autophagic proteins. This evidence concerns the gene BCL2L1 and Miyoshi myopathy.