An important mechanism of action is that IMiDs bind to CRBN-DDB1 E3 ubiquitin ligase and stabilize CRBN by inhibiting its own ubiquitination, thus increasing the degradation of key transcription factors IKZF1 (Ikaros) and IKZF3 (Aiolos) in MM through the ubiquitination-proteasome system [48]. This evidence concerns the gene IKZF3 and Miyoshi myopathy.