Representative tumor images from vehicle, paclitaxel, and sabizabulin treatment groups are shown in Figure 5E. Evaluation of apoptosis by cleaved caspase-3 immumohistochemsitry revealed no significant differences relative to vehicle-treated tumors for paclitaxel or for sabizabulin, or between paclitaxel and sabizabulin (Figure 5F,G). The gene discussed is CASP3; the disease is neoplasm.