Suppression of SRGN in LN-18 glioblastoma cells triggers the downregulation of several pluripotency and self-renewal markers, such as SOX2, OCT4, LIF, MSI1, NES, KLF4, Nanog, and ALDH-1, while it simultaneously upregulates the expression of astrocyte differentiation factors including GFAP, SPARCL-1, and Snail. This evidence concerns the gene SRGN and glioblastoma.