In esophageal squamous cell carcinoma cells, recombinant human endostatin treatment combined with irradiation leads to the upregulation of PTEN and E-cadherin and inhibition of AKT/GSK-3β/Snail signaling axis and EMT, suggesting that this combination could be a potential approach for metastasis suppression [94] (Table 1). Here, PTEN is linked to esophageal squamous cell carcinoma.