Cytoplasmic ASPN can recruit the TGFβ-induced p-SMAD2/3 on the nuclear membrane, facilitating their transportation to the nucleus inducing the expression of EMT-related genes, such as MMP-2, MMP-9, AHR, GLI2, ZEB1, TCF4, and TNC in colorectal cancer cells [69] (Table 1). The gene discussed is TGFB1; the disease is colorectal cancer.