MiR-323b-3p is upregulated and TGFBR3 is downregulated in osteosarcoma to evoke tumorigenesis, with the opposite expression pattern being true in pulmonary metastasis where TGFBR3 acts as a tumor promoter for the development of pulmonary metastasis [136]. The gene discussed is TGFBR3; the disease is osteosarcoma.