Moreover, they found that miR-940, miR-451a/miR-16-5p, and miR-17-3p target PTEN, IGF1R, and SRC mRNA, respectively, whose aberrant signaling was described as a mechanism involved in trastuzumab resistance of breast cancer cells [58,59,60,61,62]. The gene discussed is IGF1R; the disease is breast carcinoma.