For example, concerning luminal B HER2+ breast cancer, it has been demonstrated that miR-718, miR-4516, miR-210, and miR-125b-5p are specifically associated with chemo-sensitivity; miR-222 and let-7g correlate with pathological response; and high levels of miR-125b-5p during neoadjuvant chemotherapy treatment predicted a poorer disease free survival [28]. The gene discussed is ERBB2; the disease is breast cancer.