Overall, the proportion of grade ≥ 3 and serious AEs, such as gastrointestinal AEs, hematological AEs, thromboembolic event, intracranial hemorrhage, hypertension, hypothyroidism, AST and ALT increase, rush, and proteinuria remained under the threshold of 0.15 for each drug. This evidence concerns the gene GPT and intracranial hemorrhage.