MAP2K7 and neoplasm: Overall, there are changes in over 140 kinases from all major subfamilies, and the profile of induced RTKs can be used to identify effective combination therapies: a combination of the MEK inhibitor selumetinib and the multi-tyrosine kinase inhibitor (TKI) sorafenib synergistically reduced proliferation and induced apoptosis in TNBC cell lines and induced tumor regression in genetically engineered mouse models.